Relaxin-1 Antibody (351713) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB
• Clone: 351713
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

Relaxin-1 Antibody (351713) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human Relaxin-1
  Lys26-Cys185
  Accession # P04808
• Specificity: Detects the precursor form of human Relaxin-1 in direct ELISAs and Western blots. Does not detect mature Relaxin-1 heterodimer. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Relaxin-2 precursor or rhRelaxin-3 precursor is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: RLN1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Relaxin-1 Antibody (351713) [Janelia Fluor® 669]

• bA12D24.3.1
• bA12D24.3.2
• H1
• preprorelaxin H1
• prorelaxin H1
• relaxin 1 (H1)
• relaxin 1
• relaxin H1
• Relaxin1
• Relaxin-1
• RLN1
• RLXH1

Background

Relaxin-1 is a protein that is 185 amino acids long, weighs approximately 21 kDa, and has a shorter isoform that is 117 amino acids long and weighs approximately 13 kDa. Relaxin-1 functions as an ovarian hormone that combines with estrogen to produce birth canal dialation as well as remodels connective tissues during pregnancy. Current studies are being done on diseases and disorders relating to this protein including diabetes mellitus, germ cell cancer, pulmonary function, neuroendocrine tumors, cryptorchidism, hepatitis, thyroiditis, breast cancer, hepatitis, hypertension, and cerebritis. Relaxin-1 has also been shown to have interactions with AR, RNF6, and RXFP1 in pathways such as the relaxin, PKC activation, myometrial relaxation and contraction, and androgen receptor signaling pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RLN1