Recombinant Human Serpin A4/Kallistatin Protein, CF Summary
Details of Functionality
Measured by its ability to inhibit KLK1 cleavage of a fluorogenic peptide substrate, Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The IC50 value is <40 nM, as measured under the described conditions.
Mouse myeloma cell line, NS0-derived human Serpin A4/Kallistatin protein Gln21-Pro427, with a C-terminal 10-His tag
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
<1.0 EU per 1 μg of the protein by the LAL method.
48 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
57 kDa and 61 kDa, reducing conditions
Read Publication using 1669-PI in the following applications:
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Recombinant Human Serpin A4/Kallistatin Protein, CF
antitrypsin), member 4
PI4Peptidase inhibitor 4
protease inhibitor 4 (kallistatin)
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Serpin A4 is a member of the Serpin superfamily of the serine protease inhibitors (1). Known also as kallistatin or proteinase inhibitor 4, Serpin A4 has been shown to function as a specific inhibitor of tissue kallikrein and as an inhibitor of angiogenesis and tumor growth (2, 3).
Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
Chen, V.C. et al. (2000) J. Biol. Chem. 275:40371.
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