Recombinant Human IL-3 Protein, CF

Recombinant Human IL-3 (Catalog #203‑IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.02‑0.1 ng/mL.

1 μg/lane of Recombinant Human IL-3 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IL-3 Protein, CF Summary

• Additional Information: Earn double rewards for reviews
• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 0.02-0.1 ng/mL.
• Source: E. coli-derived human IL-3 protein
  Ala20-Phe152, with and without an N-terminal Met
• Accession #: AAC08706
• N-terminal Sequence: Ala20 and Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: IL3
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 15 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-3 Protein, CF

• Hematopoietic growth factor
• IL3
• IL-3
• IL-3MGC79398
• interleukin 3 (colony-stimulating factor, multiple)
• interleukin-3
• Mast cell growth factor
• mast-cell growth factor
• MCGF
• MCGFMGC79399
• MULTI-CSF
• multilineage-colony-stimulating factor
• Multipotential colony-stimulating factor
• P-cell stimulating factor
• P-cell-stimulating factor

Background

Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor, P-cell stimulating factor, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes can also produce IL-3. At the amino acid sequence level, mature human and murine IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on murine cells.

IL-3 exerts its biological activities through binding to specific cell surface receptors. The high affinity receptor responsible for IL-3 signaling is composed of at least two subunits, an IL-3 specific alpha chain which binds IL-3 with low affinity and a common beta chain that is shared by the IL-5 and GM-CSF high-affinity receptors. Although the beta chain itself does not bind IL-3, it confers high-affinity IL-3 binding in the presence of the  alpha chain. Receptors for IL-3 are present on bone marrow progenitors, macrophages, mast cells, eosinophils, megakaryocytes, basophils and various myeloid leukemic cells.

Publications for IL-3 (203-IL/CF)(195)

Publications using 203-IL/CF

• Goeckel, ME;Lee, J;Levitas, A;Colijn, S;Mun, G;Burton, Z;Chintalapati, B;Yin, Y;Abello, J;Stratman, A; CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment bioRxiv : the preprint server for biology 2023-09-17 [PMID: 37745440] (Cell Culture, Human)
• AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G&gt;A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)
• JR James, J Curd, JC Ashworth, M Abuhantash, M Grundy, CH Seedhouse, KP Arkill, AJ Wright, CLR Merry, A Thompson Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML International Journal of Molecular Sciences, 2023-02-20;24(4):. 2023-02-20 [PMID: 36835644] (Bioassay, Human)
• L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)
• S Takase, T Hiroyama, F Shirai, Y Maemoto, A Nakata, M Arata, S Matsuoka, T Sonoda, H Niwa, S Sato, T Umehara, M Shirouzu, Y Nishigaya, T Sumiya, N Hashimoto, R Namie, M Usui, T Ohishi, SI Ohba, M Kawada, Y Hayashi, H Harada, T Yamaguchi, Y Shinkai, Y Nakamura, M Yoshida, A Ito A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression Nature Communications, 2023-01-12;14(1):23. 2023-01-12 [PMID: 36635268] (Bioassay, Human)
• X Wang, S Cooper, HE Broxmeyer, R Kapur Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment Leukemia, 2022-12-02;0(0):. 2022-12-02 [PMID: 36460765] (Cell Culture, Human)
• PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture Oncogene, 2022-11-14;65(0):102973. 2022-11-14 [PMID: 36455383] (Bioassay, Human)
• X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Human)
• Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)
• N Vilaplana-, V Cuminetti, R Almaghrabi, G Papatzikas, AK Rout, M Jeeves, E González, Y Alyahyawi, A Cunningham, A Erdem, F Schnütgen, M Raghavan, S Potluri, JB Cazier, JJ Schuringa, MAC Reed, L Arranz, UL Günther, P Garcia Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Elife, 2022-09-02;11(0):. 2022-09-02 [PMID: 36052997] (Bioassay, Human)
• YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)
• BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot Human iPSC co-culture model to investigate the interaction between microglia and motor neurons Scientific Reports, 2022-07-23;12(1):12606. 2022-07-23 [PMID: 35871163] (Bioassay, Human)
• IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder Oncogene, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840799] (Bioassay, Human)
• S Wahlen, F Matthijsse, W Van Loocke, S Taveirne, L Kiekens, E Persyn, E Van Ammel, Z De Vos, S De Munter, P Matthys, F Van Nieuwe, T Taghon, B Vandekerck, P Van Vlierb, G Leclercq The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency Elife, 2022-07-06;11(0):. 2022-07-06 [PMID: 35793229] (Bioassay, Human)
• L Liu, A Vujovic, NP Deshpande, S Sathe, G Anande, HTT Chen, J Xu, MD Minden, GW Yeo, A Unnikrishn, KJ Hope, Y Lu The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors Nature Communications, 2022-07-04;13(1):3833. 2022-07-04 [PMID: 35781533] (Bioassay, Human)
• BA Krishna, AB Wass, EA Murphy, CM O'Connor Design of a US28 ORF Deletion Virus in a Temperature-Sensitive Cytomegalovirus Strain Fails to Promote Lytic Replication in Hematopoietic Cells Viruses, 2022-06-12;14(6):. 2022-06-12 [PMID: 35746751] (Bioassay, Human)
• Q Lian, K Zhang, Z Zhang, F Duan, L Guo, W Luo, BW Mok, A Thakur, X Ke, P Motallebne, V Nicolaescu, J Chen, CY Ma, X Zhou, S Han, T Han, W Zhang, AY Tan, T Zhang, X Wang, D Xu, J Xiang, A Xu, C Liao, FP Huang, YW Chen, J Na, G Randall, HF Tse, Z Chen, Y Chen, HJ Chen Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model Nature Communications, 2022-04-19;13(1):2028. 2022-04-19 [PMID: 35440562] (Bioassay, Human)
• Y Liu, Y Liu, Y Jia, J Lv, D Sun, Y Yin, N Liu, B Su, G Sun Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation Stem Cell Research, 2022-03-11;61(0):102745. 2022-03-11 [PMID: 35381520] (Bioassay, Human)
• AV Jacobsen, CL Pierotti, KN Lowes, AE Au, Y Zhang, N Etemadi, C Fitzgibbon, WJA Kersten, AL Samson, MF van Delft, DCS Huang, HJ Sabroux, G Lessene, J Silke, JM Murphy The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL Cell Death & Disease, 2022-04-01;13(4):291. 2022-04-01 [PMID: 35365636] (Cell Culture, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)
• Y Dong, X Li, W Fu, X Tian, G Guo, Y Peng, Y Zhai, J Zhao, Z Ding, X Zhao, J Dong Generation of an iPSC line (ZZUNEUi021-A) from a hypertrophic cardiomyopathy patient with TNNT2 mutation Stem Cell Research, 2021-12-11;58(0):102622. 2021-12-11 [PMID: 34929444] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322]
• C Tipgomut, A Khuhapinan, MC Wilson, S Poldee, KJ Heesom, C Metheetrai, O Sripichai, C Mitrpant, J Frayne, K Trakarnsan MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera Scientific Reports, 2021-11-18;11(1):22483. 2021-11-18 [PMID: 34795367] (Bioassay, Human)
• GB Schwartz, H Kubo, MM Laronda Generation of two human induced pluripotent stem cell lines from a patient with complete androgen insensitivity syndrome with a hemizygous single nucleotide variant in the androgen receptor (AR) gene Stem Cell Research, 2021-06-30;55(0):102441. 2021-06-30 [PMID: 34233262] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, V Thaker Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity Stem Cell Research, 2021-06-21;54(0):102432. 2021-06-21 [PMID: 34214899] (Bioassay, Human)
• S Simón Serr, M Tavecchio, A Grönberg, W Sime, M Jemaà, S Moss, MA Gregory, P Gallay, E Elmér, MJ Hansson, R Massoumi Novel Cyclophilin Inhibitor Decreases Cell Proliferation and Tumor Growth in Models of Hepatocellular Carcinoma Cancers, 2021-06-18;13(12):. 2021-06-18 [PMID: 34207224] (Bioassay, Human)
• GA Newby, JS Yen, KJ Woodard, T Mayuranath, CR Lazzarotto, Y Li, H Sheppard-T, SN Porter, Y Yao, K Mayberry, KA Everette, Y Jang, CJ Podracky, E Thaman, C Lechauve, A Sharma, JM Henderson, MF Richter, KT Zhao, SM Miller, T Wang, LW Koblan, AP McCaffrey, JF Tisdale, TA Kalfa, SM Pruett-Mil, SQ Tsai, MJ Weiss, DR Liu Base editing of haematopoietic stem cells rescues sickle cell disease in mice Nature, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079130] (Bioassay, Human)
• J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients Stem Cell Research, 2021-05-25;54(0):102407. 2021-05-25 [PMID: 34062330] (Bioassay, Human)
• S Matsuo, Y Nishinaka-, Y Kazuki, M Oshimura, T Nakahata, A Niwa, MK Saito Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification PLoS ONE, 2021-03-29;16(3):e0247595. 2021-03-29 [PMID: 33780474] (Bioassay, Human)
• S Jung, E Appleton, M Ali, GM Church, A Del Sol A computer-guided design tool to increase the efficiency of cellular conversions Nature Communications, 2021-03-12;12(1):1659. 2021-03-12 [PMID: 33712564] (Bioassay, Human)
• AL Kennedy, KC Myers, J Bowman, CJ Gibson, ND Camarda, E Furutani, GM Muscato, RH Klein, K Ballotti, S Liu, CE Harris, A Galvin, M Malsch, D Dale, JM Gansner, TA Nakano, A Bertuch, A Vlachos, JM Lipton, P Castillo, J Connelly, J Churpek, JR Edwards, N Hijiya, RH Ho, I Hofmann, JN Huang, S Keel, A Lamble, BW Lau, M Norkin, E Stieglitz, W Stock, K Walkovich, S Boettcher, C Brendel, MD Fleming, SM Davies, EA Weller, C Bahl, SL Carter, A Shimamura, RC Lindsley Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome Nature Communications, 2021-02-26;12(1):1334. 2021-02-26 [PMID: 33637765] (Bioassay, Human)
• T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021-02-10;0(0):. 2021-02-10 [PMID: 33571445] (Bioassay, Human)
• P Gonzalez-M, M Romano, H Yan, R Deshmukh, J Papoin, L Oburoglu, M Daumur, AS Dumé, I Phadke, C Mongellaz, X Qu, PN Bories, M Fontenay, X An, V Dardalhon, M Sitbon, VS Zimmermann, PG Gallagher, S Tardito, L Blanc, N Mohandas, N Taylor, S Kinet An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism Cell Reports, 2021-02-02;34(5):108723. 2021-02-02 [PMID: 33535038] (Bioassay, Human)
• S Chen, L Yang, B Nilsson-Pa, Y Han, F Jaffré, J Zhu, P Wang, T Zhang, D Redmond, S Houghton, R Møller, D Hoagland, S Horiuchi, J Acklin, J Lim, Y Bram, C Richardson, V Chandar, A Borczuk, Y Huang, J Xiang, D Ho, R Schwartz, B tenOever, T Evans SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2 Res Sq, 2020-11-17;0(0):. 2020-11-17 [PMID: 33236003] (Bioassay, Human)
• K Trakarnsan, C Tipgomut, C Metheetrai, M Wattanapan, A Khuhapinan, S Poldee, R Kurita, Y Nakamura, C Srisawat, J Frayne Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E/&amp;beta-thalassemia patient Sci Rep, 2020-10-08;10(1):16798. 2020-10-08 [PMID: 33033327] (Bioassay, Human)
• R Leylek, M Alcántara-, JM Granja, M Chavez, K Perez, OR Diaz, R Li, AT Satpathy, HY Chang, J Idoyaga Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity Cell Rep, 2020-09-22;32(12):108180. 2020-09-22 [PMID: 32966789] (Bioassay, Human)
• S Riccetti, A Sinigaglia, G Desole, N Nowotny, M Trevisan, L Barzon Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells Viruses, 2020-08-12;12(8):. 2020-08-12 [PMID: 32806715] (Bioassay, Human)
• BA Krishna, AB Wass, CM O'Connor Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency Proc. Natl. Acad. Sci. U.S.A., 2020-08-11;117(34):20860-20867. 2020-08-11 [PMID: 32788362] (Bioassay, Human)
• N Thornton, V Karamatic, L Tilley, CA Green, CL Tay, RE Griffiths, BK Singleton, F Spring, P Walser, AG Alattar, B Jones, R Laundy, JR Storry, M Möller, L Wall, R Charlewood, CM Westhoff, C Lomas-Fran, V Yahalom, U Feick, A Seltsam, B Mayer, ML Olsson, DJ Anstee Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype Nat Commun, 2020-07-16;11(1):3569. 2020-07-16 [PMID: 32678083] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)
• PR Norden, Z Sun, GE Davis Control of endothelial tubulogenesis by Rab and Ral GTPases, and apical targeting of caveolin-1-labeled vacuoles PLoS ONE, 2020-06-22;15(6):e0235116. 2020-06-22 [PMID: 32569321] (Bioassay, Human)
• X Xiao, P Liu, D Li, Z Xia, P Wang, X Zhang, M Liu, L Liao, B Jiao, R Ren Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition J Hematol Oncol, 2020-06-18;13(1):80. 2020-06-18 [PMID: 32552902] (Bioassay, Human)
• J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020-06-02;31(9):107688. 2020-06-02 [PMID: 32492433] (Cell Culture, Human)
• M Meinders, D Shoemark, JGG Dobbe, GJ Streekstra, J Frayne, AM Toye Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE Mol Ther Methods Clin Dev, 2020-04-01;17(0):822-830. 2020-04-01 [PMID: 32368563] (Cell Culture, Human)
• MAE Rab, BA van Oirsch, PA Kosinski, J Hixon, K Johnson, V Chubukov, L Dang, G Pasterkamp, S van Straat, WW van Soling, EJ van Beers, C Kung, R van Wijk AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes Haematologica, 2021-01-01;0(0):. 2021-01-01 [PMID: 31974203] (Cell Culture, Human)
• CD Lemke-Milt, SE Blackwell, C Yin, AE Krug, AJ Morris, AM Krieg, GJ Weiner Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization J. Immunol., 2020-01-17;204(5):1386-1394. 2020-01-17 [PMID: 31953355] (Bioassay, Human)
• R Leylek, M Alcántara-, Z Lanzar, A Lüdtke, OA Perez, B Reizis, J Idoyaga Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population Cell Rep, 2019-12-10;29(11):3736-3750.e8. 2019-12-10 [PMID: 31825848] (Cell Culture, Human)
• VA Balaji Rag, M Anwar, MZ Akhter, A Chavez, Y Mao, V Natarajan, S Lakshmikan, M Chrzanowsk, AZ Dudek, L Claesson-W, JK Kitajewski, KK Wary, AB Malik, D Mehta Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling Cell Rep, 2019-12-10;29(11):3472-3487.e4. 2019-12-10 [PMID: 31825830] (Human)
• AT Stefka, D Johnson, S Rosebeck, JH Park, Y Nakamura, AJ Jakubowiak Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models Cancer Med, 2019-11-12;0(0):. 2019-11-12 [PMID: 31714026] (Cell Culture, Human)
• JP Ruiz, G Chen, JJ Haro Mora, K Keyvanfar, C Liu, J Zou, J Beers, H Bloomer, H Qanash, N Uchida, JF Tisdale, M Boehm, A Larochelle Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system Stem Cell Res, 2019-10-15;41(0):101600. 2019-10-15 [PMID: 31710911] (Cell Culture, Mouse)
• J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)
• WR Proto, SV Siegel, S Dankwa, W Liu, A Kemp, S Marsden, ZA Zenonos, S Unwin, PM Sharp, GJ Wright, BH Hahn, MT Duraisingh, JC Rayner Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand Nat Commun, 2019-10-04;10(1):4512. 2019-10-04 [PMID: 31586047] (Cell Culture, Human)
• N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders Nat Commun, 2019-10-02;10(1):4479. 2019-10-02 [PMID: 31578323] (Cell Culture, Human)
• M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance Cancer Res., 2019-09-13;0(0):. 2019-09-13 [PMID: 31519687] (Bioassay, Human)
• MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia Cell Stem Cell, 2019-08-01;25(2):258-272.e9. 2019-08-01 [PMID: 31374198] (Cell Culture, Human)
• M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)
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• RHP Wilbers, DR van Raaij, LB Westerhof, J Bakker, G Smant, A Schots Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain PLoS ONE, 2017-10-10;12(10):e0186317. 2017-10-10 [PMID: 29016674] (Bioassay, Mouse)
• S Radecke, K Schwarz, F Radecke Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments Mol. Ther., 2017-09-15;26(1):115-131. 2017-09-15 [PMID: 28988714] (Bioassay, Human)
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• CY Chiu, SC Su, WL Fan, SH Lai, MH Tsai, SH Chen, KS Wong, WH Chung Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption Sci Rep, 2017-02-24;7(0):43469. 2017-02-24 [PMID: 28233860] (Bioassay, Human)
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• Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Immunology, 2016-09-30;0(0):. 2016-09-30 [PMID: 27568595] (Bioassay, Human)
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• Lederle A, Su B, Holl V, Penichon J, Schmidt S, Decoville T, Laumond G, Moog C Neutralizing antibodies inhibit HIV-1 infection of plasmacytoid dendritic cells by an FcgammaRIIa independent mechanism and do not diminish cytokines production. Sci Rep, 2014-08-18;4(0):5845. 2014-08-18 [PMID: 25132382] (Bioassay, Human)
• Xia C, Peng R, Chernatynskaya A, Yuan L, Carter C, Valentine J, Sobel E, Atkinson M, Clare-Salzler M Increased IFN-alpha-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-alpha production. J Immunol, 2014-06-27;193(3):1024-34. 2014-06-27 [PMID: 24973447] (Bioassay, Human)
• Lin A, Burrascano C, Pettersson P, Ibanez C, Gruber H, Jolly D Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity. J Virol, 2014-06-25;88(17):10066-77. 2014-06-25 [PMID: 24965455] (Bioassay, Human)
• Smith , Laura J, Ul-Hasan , Taihra, Carvaines , Sarah K, Van Vliet , Kim, Yang , Ethel, Wong , Kamehame, Agbandje-McKenna , Mavis, Chatterjee , Saswati Gene transfer properties and structural modeling of human stem cell-derived AAV. Mol Ther, 2014-06-13;22(9):1625-34. 2014-06-13 [PMID: 24925207] (Bioassay, Human)
• Jitkova , Yulia, Gronda , Marcela, Hurren , Rose, Wang , Xiaoming, Goard , Carolyn, Jhas , Bozhena, Schimmer , Aaron D A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS ONE, 2014-05-28;9(5):e95281. 2014-05-28 [PMID: 24871339] (Bioassay, Human)
• Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins. Br J Haematol, 2014-05-16;166(3):435-48. 2014-05-16 [PMID: 24837254] (Bioassay, Human)
• Morshed M, Hlushchuk R, Simon D, Walls A, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon H, Yousefi S NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol, 2014-04-25;192(11):5314-23. 2014-04-25 [PMID: 24771850] (Bioassay, Human)
• Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R Epigenetic reprogramming induces the expansion of cord blood stem cells. J Clin Invest, 2014-04-24;124(6):2378-95. 2014-04-24 [PMID: 24762436] (Bioassay, Human)
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• Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 2014-04-03;123(20):3116-27. 2014-04-03 [PMID: 24700781] (Bioassay, Human)
• Li X, Romain R, Park D, Scadden D, Merchant J, Arnaout M Stress hematopoiesis is regulated by the Kruppel-like transcription factor ZBP-89. Stem Cells, 2014-03-01;32(3):791-801. 2014-03-01 [PMID: 24549639] (Bioassay, Human)
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• van Wilgenburg , Bonnie, Moore , Michael, James , William, Cowley , Sally A The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4. PLoS ONE, 2014-01-22;9(1):e86071. 2014-01-22 [PMID: 24465876] (Bioassay, Human)
• Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014-05-01;32(5):1337-46. 2014-05-01 [PMID: 24446170] (Bioassay, Human)
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• Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood, 2013-12-18;123(8):1239-49. 2013-12-18 [PMID: 24352879] (Bioassay, Human)
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• Thanunchai , Maytawan, Kanrai , Pumaree, Wiboon-Ut , Suwimon, Puthavathana , Pilaipan, Hongeng , Suradej, Thitithanyanont , Arunee Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells. PLoS ONE, 2013-12-10;8(12):e81805. 2013-12-10 [PMID: 24339969] (Bioassay, Human)
• Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 2013-12-06;134(5):1246-54. 2013-12-06 [PMID: 24317394] (Bioassay, Human)
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• Yu , Jianhua, Peng , Yong, Wu , Lai-Chu, Xie , Zhiliang, Deng , Youcai, Hughes , Tiffany, He , Shun, Mo , XiaoKui, Chiu , Ming, Wang , Qi-En, He , Xiaoming, Liu , Shujun, Grever , Michael, Chan , Kenneth, Liu , Zhongfa Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE, 2013-02-13;8(2):e55934. 2013-02-13 [PMID: 23457487] (Bioassay, Human)
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• Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer, 2012-09-26;12(0):431. 2012-09-26 [PMID: 23013471] (Bioassay, Human)
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• Gupta N, Barhanpurkar AP, Tomar GB IL-3 inhibits human osteoclastogenesis and bone resorption through downregulation of c-Fms and diverts the cells to dendritic cell lineage. J. Immunol., 2010-07-19;185(4):2261-72. 2010-07-19 [PMID: 20644169] (Bioassay, Human)
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• Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood, 2009-10-12;114(24):5091-101. 2009-10-12 [PMID: 19822899] (Bioassay, Human)
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• Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin&#039;s lymphoma. Int. J. Cancer, 2009-09-01;125(5):1092-101. 2009-09-01 [PMID: 19391137] (Bioassay, Human)
• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)
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• McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)
• Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Human, Mouse, Primate - Macaca mulatta (Rhesus Macaque))
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• Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J. Immunol., 2006-07-01;177(1):77-83. 2006-07-01 [PMID: 16785501] (Bioassay, Human)
• Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis. Eur. J. Immunol., 2006-07-01;36(7):1975-84. 2006-07-01 [PMID: 16761316] (Bioassay, Human)
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Bioinformatics

• Gene Symbol: IL3
• Uniprot:
  • AAC08706()