Recombinant Human ALK-1 Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human ALK-1 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit BMP-9-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is 3-12 ng/mL in the presence of 2 ng/mL of rhBMP-9.
Mouse myeloma cell line, NS0-derived human ALK-1 protein
Human ALK-1
(Asp22 - Gln118)
Accession # P37023.2
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
37.3 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
50-55 kDa, reducing conditions
Read Publications using
370-AL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human ALK-1 Fc Chimera Protein, CF

  • activin A receptor type II-like 1
  • activin A receptor, type II-like kinase 1
  • Activin receptor-like kinase 1
  • ACVRL1
  • ALK1
  • ALK-1
  • ALK1TGF-B superfamily receptor type I
  • EC 2.7.11
  • HHT
  • HHT2EC
  • serine/threonine-protein kinase receptor R3
  • SKR3
  • TSR-I


Transforming Growth Factor beta (TGF-beta ) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) of serine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGF-beta superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor-like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK-2, -3, -4, -5, and -6 are also known as Activin R1A, BMPR-1A, Activin R1B, TGF-beta R1, and BMPR-1B, respectively, reflecting their ligand preferences. Evidence suggests that TGF-beta 1, TGF-beta 3 and an unknown ligand present in serum can activate chimeric ALK-1. ALK-1 shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycine- and serine-rich domain (the GS domain) preceding the kinase domain. ALK-1 is expressed highly in endothelial cells and other highly vascularized tissues. The expression patterns of ALK-1 parallels that of endoglin. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting a critical role for ALK-1 in the control of blood vessel development or repair. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular regions.

  1. ten Dijke, P. et al. (1993) Oncogene 8:2879.
  2. ten Dijke, P. et al. (1994) Science 264:101.
  3. Lux, A. et al. (1999) J. Biol. Chem. 274:9984.

Publications for ALK-1 (370-AL)(14)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, Immunoprecipitation, Surface Plasmon Resonance.

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Cell Culture
Surface Plasmon Resonance
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Showing Publications 1 - 10 of 14. Show All 14 Publications.
Publications using 370-AL Applications Species
PL Mendez, L Obendorf, J Jatzlau, W Burdzinski, M Reichenbac, V Nageswaran, A Haghikia, V Stangl, C Hiepen, P Knaus Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes Bmc Biology, 2022-09-28;20(1):210. 2022-09-28 [PMID: 36171573] (Bioassay, Human) Bioassay Human
J Guo, B Liu, M Thorikay, M Yu, X Li, Z Tong, RM Salmon, RJ Read, P Ten Dijke, NW Morrell, W Li Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10 Nature Communications, 2022-05-03;13(1):2395. 2022-05-03 [PMID: 35504921] (Surface Plasmon Resonance, Human) Surface Plasmon Resonance Human
T Toyonaga, EC Steinbach, BP Keith, JB Barrow, MR Schaner, EA Wolber, C Beasley, J Huling, Y Wang, NL Allbritton, N Chaumont, TS Sadiq, MJ Koruda, A Jain, MD Long, EL Barnes, HH Herfarth, KL Isaacs, JJ Hansen, MT Shanahan, R Rahbar, TS Furey, P Sethupathy, SZ Sheikh Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients with Crohn&#039;s disease Cell Mol Gastroenterol Hepatol, 2020-06-16;0(0):. 2020-06-16 [PMID: 32561494] (Bioassay, Human) Bioassay Human
J Wu, B Wei, Y Shi, X Lu, Y Ding, C Wang, Y Li Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX Mol Med Rep, 2019-07-31;20(4):3233-3239. 2019-07-31 [PMID: 31432109] (Cell Culture, Human) Cell Culture Human
OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien TGF-? contamination of purified recombinant GDF15 PLoS ONE, 2017-11-21;12(11):e0187349. 2017-11-21 [PMID: 29161287] (Bioassay, Human) Bioassay Human
A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10 Sci Rep, 2016-11-22;5(0):37366. 2016-11-22 [PMID: 27874028] (Bioassay, Human) Bioassay Human
Woltje K, Jabs M, Fischer A Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE, 2015-03-23;10(3):e0120547. 2015-03-23 [PMID: 25799559] (Bioassay, Human) Bioassay Human
Wu , Qifang, Sun , Chia Chi, Lin , Herbert, Babitt , Jodie L Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 2012-09-27;7(9):e46307. 2012-09-27 [PMID: 23029472] (Surface Plasmon Resonance, Human) Surface Plasmon Resonance Human
van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J. Biol. Chem., 2012-04-05;287(22):18551-61. 2012-04-05 [PMID: 22493445] (Surface Plasmon Resonance, Human) Surface Plasmon Resonance Human
Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Bostrom KI Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood, 2012-04-03;119(21):5037-47. 2012-04-03 [PMID: 22474252] (Bioassay, Human) Bioassay Human
Show All 14 Publications.

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Gene Symbol ACVRL1