Rad21 Antibody (CM110-2C10) [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clone
CM110-2C10
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

Rad21 Antibody (CM110-2C10) [DyLight 550] Summary

Immunogen
An N-terminal fusion protein of the C-terminal fragment of Scc1 subunit human cohesin (amino acids 544-631 of hRad21).
Localization
Nuclear and cytoplasm
Specificity
NB100-386 is specific for both the nuclear hRad21 protein and the cleaved cytoplasmic hRad21 protein.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
RAD21
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This Rad21 (CM110-2C10) antibody can be used in Western blot, where two bands are seen. The full-length Rad21 is seen around 130 kDa, while the cleaved Rad21 is seen around 70 kDa.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Rad21 Antibody (CM110-2C10) [DyLight 550]

  • double-strand-break repair protein rad21 homolog
  • hHR21FLJ25655
  • HR21
  • KIAA0078RAD21 (S. pombe) homolog
  • MCD1
  • Nuclear matrix protein 1
  • NXP-1
  • NXP1HRAD21
  • protein involved in DNA double-strand break repair
  • RAD21 homolog (S. pombe)
  • SCC1 homolog
  • SCC1FLJ40596

Background

The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB100-386B
DyLight 405 Labeled NB100-386V
DyLight 488 Labeled NB100-386G
DyLight 650 Labeled NB100-386C
HRP Labeled NB100-386H

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Bioinformatics Tool for Rad21 Antibody (NB100-386R)

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Bioinformatics

Gene Symbol RAD21