PTS Antibody (2B2)

Product Discontinued

PTS Antibody (2B2) Summary

• Immunogen: Recombinant human PTS (1-145aa) purified from E. coli
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTS
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:500
• Application Notes: The antibody has been tested by ELISA, Western blot to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:250 ~ 1000. Recommended starting dilution is 1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 10% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein G purified

Alternate Names for PTS Antibody (2B2)

• 6-pyruvoyl tetrahydrobiopterin synthase
• 6-pyruvoyltetrahydropterin synthase
• EC 4.2.3.12
• FLJ97081
• PTPSPTP synthase

Background

PTS or PTPS (6-Pyruvoyl tetrahydroprotein synthase) is involved in the biosynthesis of tetahydrobiopterin (BH4), the cofactor of several enzymes such as the nitric oxide synthase and the aromatic amino acid hdroxylases. Inherited deficiency of PTS is the most frequent cause of hyperphenylalninemia (HPA) characterized by depletion of the biogenic amine neutotransmitters, dopamine and serotonin, and is accompanied by severe progressive mental retardation. PTS was showed a homohexameric enzyme composed of a dimer or trimers in the crystallography and several experiments.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTS
• Uniprot:
  • NP_000308(Human)