PTP rho/PTPRT Antibody

Western Blot: PTP rho/PTPRT Antibody [NBP1-81524] - Analysis in human cerebral cortex tissue.

Immunohistochemistry-Paraffin: PTP rho/PTPRT Antibody [NBP1-81524] - Staining of human skeletal muscle shows very weak positivyt in myocytes as expected.

Immunohistochemistry-Paraffin: PTP rho/PTPRT Antibody [NBP1-81524] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells, glial cells and neuropil.

Immunohistochemistry-Paraffin: PTP rho/PTPRT Antibody [NBP1-81524] - Staining of human fallopian tube shows strong ctyoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: PTP rho/PTPRT Antibody [NBP1-81524] - Staining of human liver shows no positivity in hepatocytes as expected.

Product Discontinued

PTP rho/PTPRT Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: VHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQG
• Predicted Species: Mouse (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRT
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
  • Western Blot 0.04 - 0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for PTP rho/PTPRT Antibody

• EC 3.1.3
• EC 3.1.3.48
• KIAA0283RPTPrho
• protein tyrosine phosphatase, receptor type, T
• PTP rho
• PTPRT
• receptor protein tyrosine phosphatase
• Receptor-type tyrosine-protein phosphatase rho
• receptor-type tyrosine-protein phosphatase T
• RPTP-rho
• R-PTP-T

Background

PTPRT is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRT