PTP rho/PTPRT Products

Description

The protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Bioinformatics

Entrez	11122 Human
Uniprot	O14522
Product By Gene ID	11122
Alternate Names	EC 3.1.3 EC 3.1.3.48 KIAA0283RPTPrho protein tyrosine phosphatase, receptor type, T PTP rho PTPRT receptor protein tyrosine phosphatase Receptor-type tyrosine-protein phosphatase rho receptor-type tyrosine-protein phosphatase T RPTP-rho R-PTP-T

Research Areas for PTP rho/PTPRT

Find related products by research area and learn more about each of the different research areas below.

Protein Phosphatase