PTP rho/PTPRT Products

Description

PTPRT is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Bioinformatics

Entrez	11122 Human
Uniprot	NP_008981 Human NP_573400 Human O14522 Human
Product By Gene ID	11122
Alternate Names	EC 3.1.3 EC 3.1.3.48 KIAA0283RPTPrho protein tyrosine phosphatase, receptor type, T receptor protein tyrosine phosphatase Receptor-type tyrosine-protein phosphatase rho receptor-type tyrosine-protein phosphatase T RPTP-rho R-PTP-T

Research Areas for PTP rho/PTPRT

Find related products by research area and learn more about each of the different research areas below.

Protein Phosphatase