PTP rho/PTPRT Antibody

Images

 
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. (anti-PTPRT)

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Chicken
Conjugate
Unconjugated

Order Details

PTP rho/PTPRT Antibody Summary

Immunogen
The immunogen for this antibody was a sequence from 383a.a. to 484a.a. from PTP rho(a 1444a.a. long protein)
Localization
Membrane; single-pass type I membrane protein.
Specificity
PTP rho
Clonality
Polyclonal
Host
Chicken
Gene
PTPRT
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.

Reactivity Notes

This antibody is reactive against Human, rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for PTP rho/PTPRT Antibody

  • EC 3.1.3
  • EC 3.1.3.48
  • KIAA0283RPTPrho
  • protein tyrosine phosphatase, receptor type, T
  • PTP rho
  • PTPRT
  • receptor protein tyrosine phosphatase
  • Receptor-type tyrosine-protein phosphatase rho
  • receptor-type tyrosine-protein phosphatase T
  • RPTP-rho
  • R-PTP-T

Background

PTP rho is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP rho is a large protein that possesses a PTP domain at the C-terminus, and multiple noncatalytic domains, which include a domain with similarity to the band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTP rho interacts with, and dephosphorylates, Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggests that it may have a role in Fas-mediated programmed cell death. PTP rho also interacts with GTPase-activating protein, and thus may function as a regulator of the Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. May be involved in both signal transduction and cellular adhesion in the CNS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PTPRT
Entrez
Uniprot