PTP rho/PTPRT Antibody

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. (anti-PTPRT)

• Reactivity: Hu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Chicken
• Conjugate: Unconjugated

PTP rho/PTPRT Antibody Summary

• Immunogen: The immunogen for this antibody was a sequence from 383a.a. to 484a.a. from PTP rho(a 1444a.a. long protein)
• Localization: Membrane; single-pass type I membrane protein.
• Specificity: PTP rho
• Clonality: Polyclonal
• Host: Chicken
• Gene: PTPRT
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:200 - 1:500
• Application Notes: Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.

Reactivity Notes

This antibody is reactive against Human, rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Chicken products cannot be exported to Canada.

Alternate Names for PTP rho/PTPRT Antibody

• EC 3.1.3
• EC 3.1.3.48
• KIAA0283RPTPrho
• protein tyrosine phosphatase, receptor type, T
• PTP rho
• PTPRT
• receptor protein tyrosine phosphatase
• Receptor-type tyrosine-protein phosphatase rho
• receptor-type tyrosine-protein phosphatase T
• RPTP-rho
• R-PTP-T

Background

PTP rho is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP rho is a large protein that possesses a PTP domain at the C-terminus, and multiple noncatalytic domains, which include a domain with similarity to the band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTP rho interacts with, and dephosphorylates, Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggests that it may have a role in Fas-mediated programmed cell death. PTP rho also interacts with GTPase-activating protein, and thus may function as a regulator of the Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. May be involved in both signal transduction and cellular adhesion in the CNS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRT
• Entrez:
  • 11122(Human)
  • 362263(Rat)
• Uniprot:
  • O14522()