PTP rho/PTPRT Antibody [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: CoraFluor 1

PTP rho/PTPRT Antibody [CoraFluor™ 1] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PTPρ/PTPRT
  Gln26-Lys725
  Accession # O14522
• Specificity: Detects human PTPρ/PTPRT in Western blots. In Western blots, no cross-reactivity with recombinant human LAR, PTPRM, K, S, G or DEP1/CD148 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PTPRT
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for PTP rho/PTPRT Antibody [CoraFluor™ 1]

• EC 3.1.3
• EC 3.1.3.48
• KIAA0283RPTPrho
• protein tyrosine phosphatase, receptor type, T
• PTP rho
• PTPRT
• receptor protein tyrosine phosphatase
• Receptor-type tyrosine-protein phosphatase rho
• receptor-type tyrosine-protein phosphatase T
• RPTP-rho
• R-PTP-T

Background

PTPRT is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRT