PTP beta/zeta/PTPRZ Antibody (122.2)

Product Discontinued

PTP beta/zeta/PTPRZ Antibody (122.2) Summary

• Immunogen: Embryonic rat brain proteoglycans
• Specificity: Receptor Tyrosine Phosphatase Beta (phosphacan)
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTPRZ1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:1000-1:2500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:1000-1:2500

Reactivity Notes

Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 30% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PTP beta/zeta/PTPRZ Antibody (122.2)

• 3F8 CSPG
• HPTPZ
• phosphacan
• protein tyrosine phosphatase, receptor-type, Z polypeptide 1
• PTP beta/zeta
• PTP18
• PTPRZ
• PTPRZ1
• PTPZ
• receptor-type, zeta polypeptide 1
• RPTPB
• RPTPbeta

Background

PTPRB is a member of the protein tyrosine phosphatase (PTP) family. The family comprises at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is a transmembrane PTP. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins, which are critical in physiological and pathological events such as cell migration, adhesion and transformation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRZ1