PSENEN/PEN2 Antibody (665521) [DyLight 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 665521
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 594

PSENEN/PEN2 Antibody (665521) [DyLight 594] Summary

• Immunogen: Peptide containing human PSENEN
  Gly89-Gly98
  Accession # Q9NZ42
• Specificity: Detects human PSENEN in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PSENEN
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PSENEN/PEN2 Antibody (665521) [DyLight 594]

• gamma-secretase subunit PEN-2
• MSTP064
• PEN-2
• PEN2hematopoietic stem/progenitor cells protein MDS033
• presenilin enhancer 2 homolog (C. elegans)
• Presenilin enhancer protein 2
• PSENEN

Background

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSENEN