PSENEN/PEN2 Products

Antibodies
PSENEN/PEN2 Antibody
PSENEN/PEN2 Antibody
NBP2-24611
Species: Hu, Mu, Rt, Bv, Ca, Eq, Op
Applications: WB
Host: Rabbit Polyclonal
PSENEN/PEN2 Antibody
PSENEN/PEN2 Antibody
NB300-227
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Polyclonal
PSENEN/PEN2 Antibody
PSENEN/PEN2 Antibody
NBP1-77268
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
PSENEN/PEN2 Overexpression Ly ...
PSENEN/PEN2 Overexpression Lysate ...
NBL1-14862
Applications: WB
Proteins
PSENEN/PEN2 Recombinant Prote ...
PSENEN/PEN2 Recombinant Protein
H00055851-P01
Species: Hu
Applications: WB, ELISA, PA
PSENEN/PEN2 Recombinant Prote ...
PSENEN/PEN2 Recombinant Protein An...
NBP2-47319PEP
Species: Hu
Applications: AC
PSENEN/PEN2 Peptide
PSENEN/PEN2 Peptide
NBP1-77268PEP
Species: Hu
Applications: AC
RNAi
PSENEN/PEN2 RNAi
PSENEN/PEN2 RNAi
H00055851-R01
Species: Hu

Description

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 55851
Alternate Names
  • PEN-2
  • Presenilin enhancer protein 2
  • MSTP064
  • PEN2hematopoietic stem/progenitor cells protein MDS033
  • gamma-secretase subunit PEN-2
  • presenilin enhancer 2 homolog (C. elegans)

Research Areas for PSENEN/PEN2

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Signal Transduction

PTMs for PSENEN/PEN2

Learn more about PTMs related to PSENEN/PEN2.

Cleavage
Glycosylation
Phosphorylation
Biotinylation
Reduction
Gamma-cleavage
Palmitoylation

Bioinformatics Tool for PSENEN/PEN2

Discover related pathways, diseases and genes to PSENEN/PEN2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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