PSENEN/PEN2 Antibody (665521) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 665521
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

PSENEN/PEN2 Antibody (665521) [Alexa Fluor® 488] Summary

• Immunogen: Peptide containing human PSENEN
  Gly89-Gly98
  Accession # Q9NZ42
• Specificity: Detects human PSENEN in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PSENEN/PEN2 Antibody (665521) [Alexa Fluor® 488]

• gamma-secretase subunit PEN-2
• MSTP064
• PEN-2
• PEN2hematopoietic stem/progenitor cells protein MDS033
• presenilin enhancer 2 homolog (C. elegans)
• Presenilin enhancer protein 2
• PSENEN

Background

Gamma-secretase subunit PSENEN, also called PEN-2 (Presenilin enhancer protein 2) is a 10 kDa member of the PEN-2 family. Human PSENEN is 101 amino acids (aa) in length, and is a multi-pass transmembrane protein. Residues 1-17 are on the luminal side of the endoplasmic reticulum or Golgi apparatus, where PSENEN is primarily located. Amino acids 18-38 form a transmembrane region, and aa 39-60 form a cytoplasmic segment. Another transmembrane segment is formed by residues 61-81, and residues 82-101 are located on the luminal side of the ER or cis-Golgi. Human PSENEN shares 96% aa sequence identity with mouse and rat PSENEN. Functionally, PSENEN is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.