Protein Kinase A Regulatory Subunit II alpha Antibody (2394D) [DyLight 405]

Product Discontinued

Protein Kinase A Regulatory Subunit II alpha Antibody (2394D) [DyLight 405] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Synthetic peptide containing Human/Mouse PKA RII alpha
  Accession # P13861
• Specificity: Detects human PKA RII alpha in direct ELISAs. Detects human and mouse PKA RII alpha in Western blots.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity: Protein A or G purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from cell culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Protein Kinase A Regulatory Subunit II alpha Antibody (2394D) [DyLight 405]

• cAMP-dependent protein kinase regulatory subunit RII alpha
• cAMP-dependent protein kinase type II-alpha regulatory subunit
• PKA RII alpha
• PKR2
• PRKAR2
• PRKAR2A
• protein kinase A, RII-alpha subunit
• protein kinase, cAMP-dependent, regulatory subunit type II alpha

Background

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.