Proteasome 26S S5 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

Proteasome 26S S5 Antibody [DyLight 650] Summary

• Immunogen: Synthetic Peptide: L(485) S E G P Y Y V K P V S T T A V E G A E(504)
• Specificity: NB120-3319 immunizing peptide corresponds to amino acid residues 485-504 from human proteasome 19S subunit S5b protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PSMD5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Proteasome 26S S5 Antibody [DyLight 650]

• KIAA007226S proteasome non-ATPase regulatory subunit 5
• proteasome (prosome, macropain) 26S subunit, non-ATPase, 5,26S proteasome subunit S5B
• S5BMGC23145,26S protease subunit S5 basic

Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSMD5