Proteasome 20S beta2 Antibody

Product Discontinued

Proteasome 20S beta2 Antibody Summary

• Immunogen: This PSMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-163 amino acids from the C-terminal region of human PSMB2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PSMB2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:25
  • Immunohistochemistry-Paraffin
  • Western Blot 1:1000
• Theoretical MW: 22.836 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 0.47 mg/ml
• Purity: Protein A purified

Alternate Names for Proteasome 20S beta2 Antibody

• EC 3.4.25.1
• HC7-I
• Macropain subunit C7-I
• MGC104215
• MGC126885
• multicatalytic endopeptidase complex subunit C7-1
• Multicatalytic endopeptidase complex subunit C7-I
• proteasome (prosome, macropain) subunit, beta type, 2
• Proteasome 20S beta2
• proteasome beta 2 subunit
• Proteasome component C7-I
• proteasome subunit beta type-2
• proteasome subunit, beta type, 2
• PSMB2

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSMB2
• Uniprot:
  • P49721(Human)