Proprotein Convertase 9/PCSK9 Antibody

Images

 
Western Blot: PCSK9 Antibody [NBP2-31364] - Western blot analysis of human lung tissue (A) using PCSK9 antibody at a concentration of 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: PCSK9 Antibody [NBP2-31364] - PCSK9 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 ...read more
Immunohistochemistry-Paraffin: PCSK9 Antibody [NBP2-31364] - IHC-P analysis of PCSK9 protein in a section of normal skin from human using 5 ug/ml concentration of PCSK9 antibody. The keratinocytes showed an expected ...read more
Western Blot: PCSK9 Antibody [NBP2-31364] - WB detection of PCSK9 partial recombinant protein by using PCSK9 antibody at a concentration of 0.5 ug/ml.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Proprotein Convertase 9/PCSK9 Antibody Summary

Immunogen
Partial recombinant human PCSK9 (between residues 100-300) [UniProt# Q8NBP7]
Localization
Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PCSK9
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunocytochemistry/Immunofluorescence 0.1 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Human. Immunogen sequence similarity: Primate/Monkey (100%), Mouse (73%), Rat (74%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Proprotein Convertase 9/PCSK9 Antibody

  • EC 3.4.21
  • EC 3.4.21.111
  • FH3
  • FH3neural apoptosis regulated convertase 1
  • HCHOLA3
  • hypercholesterolemia, autosomal dominant 3
  • LDLCQ1
  • NARC-1
  • NARC-1convertase subtilisin/kexin type 9 preproprotein
  • NARC1EC 3.4.21.-
  • Neural apoptosis-regulated convertase 1
  • PC9
  • PCSK9
  • Proprotein Convertase 9
  • proprotein convertase subtilisin/kexin type 9
  • Subtilisin/kexin-like protease PC9

Background

The proprotein convertase subtilisin kexin 9 is a key regulator in plasma cholesterol metabolism. It is known to bind to a number of low-density lipid receptor family members: LDLR, VLDLR, LRP1/APOER, and LRP8/APOER2. When bound, PCSK9 regulates the levels of LDL receptors, plasma membrane glycoproteins that remove cholesterol-rich LDL particles from the plasma. The removal of LDL receptors involves internalization of the PCSK9-LDL complex and then fusion with an acidic endosome. [PMCID: PMC2386899]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PCSK9
Entrez
OMIM
Uniprot