Proprotein Convertase 9/PCSK9 Antibody

Product Discontinued

Proprotein Convertase 9/PCSK9 Antibody Summary

• Immunogen: Peptide with sequence TRFHRQASKCDSHGT corresponding to internal region according to NP_777596.2.
• Epitope: TRFHRQASKCDSHGT
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PCSK9
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 ug/mL
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 1 - 2 ug/mL

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Proprotein Convertase 9/PCSK9 Antibody

• EC 3.4.21
• EC 3.4.21.111
• FH3
• FH3neural apoptosis regulated convertase 1
• FHCL3
• HCHOLA3
• hypercholesterolemia, autosomal dominant 3
• LDLCQ1
• NARC1
• NARC-1
• NARC-1convertase subtilisin/kexin type 9 preproprotein
• NARC1EC 3.4.21.-
• Neural apoptosis-regulated convertase 1
• PC9
• PCSK9
• Proprotein Convertase 9
• proprotein convertase subtilisin/kexin type 9
• Subtilisin/kexin-like protease PC9

Background

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Proprotein Convertase 9/PCSK9 Antibody (NBP1-51933)(1)

Publication using NBP1-51933

• Kwon HJ, Lagace TA, McNutt MC et al. Molecular basis for LDL receptor recognition by PCSK9. Proc Natl Acad Sci U S A 2008-02-12 [PMID: 18250299]

Bioinformatics

• Gene Symbol: PCSK9
• Entrez:
  • 255738(Human)
• Uniprot:
  • NP_777596.2(Human)