Proprotein Convertase 9/PCSK9 Antibody

Images

 
Western Blot: Proprotein Convertase 9/PCSK9 Antibody [NBP1-51923] - HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with NBP1-51923 (0.5ug/ml) in Lane A and probed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

Proprotein Convertase 9/PCSK9 Antibody Summary

Immunogen
Peptide with sequence C-PRYRADEYQPPD corresponding to internal region according to NP_777596.2.
Epitope
C-PRYRADEYQPPD
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PCSK9
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.5 ug/ml
  • Immunoprecipitation 1:10 - 1:500
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: In transfected HEK293 transiently expressing full-length human PCSK9 (myc and DYKDDDDK tagged), a doublet of approx. 80-100 kDa band was observed. No bands were observed in mock-transfected HEK293 and the same bands were observed using anti-myc tag antibody.
Publications
Read Publication using NBP1-51923.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Proprotein Convertase 9/PCSK9 Antibody

  • EC 3.4.21
  • EC 3.4.21.111
  • FH3
  • FH3neural apoptosis regulated convertase 1
  • HCHOLA3
  • hypercholesterolemia, autosomal dominant 3
  • LDLCQ1
  • NARC-1
  • NARC-1convertase subtilisin/kexin type 9 preproprotein
  • NARC1EC 3.4.21.-
  • Neural apoptosis-regulated convertase 1
  • PC9
  • PCSK9
  • Proprotein Convertase 9
  • proprotein convertase subtilisin/kexin type 9
  • Subtilisin/kexin-like protease PC9

Background

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Proprotein Convertase 9/PCSK9 Antibody (NBP1-51923)(1)

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Video Protocols

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Bioinformatics

Gene Symbol PCSK9
Entrez
Uniprot