Progesterone R B/NR3C3 Antibody (569012) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 569012
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

Progesterone R B/NR3C3 Antibody (569012) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human Progesterone R B in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Progesterone R B/NR3C3 Antibody (569012) [Alexa Fluor™ Plus 594]

• PGRB
• Progesterone R B
• Progesterone RB

Background

Progesterone Receptor B (PR-B) is a 118 kDa member of the NR3 subfamily within the nuclear hormone receptor family of proteins. It is expressed in several tissues, including female reproductive organs as well as neurons throughout the CNS. PR-B is particularly important in the mammary gland where it mediates proliferative responses to progesterone. Human PR-B contains an N-terminal regulatory region (aa1‑566), a DNA binding domain (aa 567‑639), and a steroid-binding region (aa 681‑933). Ligand binding induces a key phosphorylation event at Ser294 by ERK1/2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.