Proenkephalin Antibody (1194/334)

Product Discontinued

Proenkephalin Antibody (1194/334) Summary

• Immunogen: Native
• Localization: Secreted
• Specificity: This product recognises Met-enkephalin a neurotransmitter that both competes with, and mimics the effects of opiate drugs. Enkephalins play a role in a number of physiologic functions, including pain perception and responses to stress. Cross reactivates with other enkephalins to be determined.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PENK
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000

Reactivity Notes

All Species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.07% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for Proenkephalin Antibody (1194/334)

• enkephalin A
• preproenkephalin
• proenkephalin
• proenkephalin-A

Background

Methionine enkephalin (met enkephalin) is a pentapeptide that appears to enhance immune function at low doses and suppresse at high doses. This molecule acts in the central nervous, neuroendocrine, and immune systems. Cells from these systems have receptors for met enkephalin and are able to generate met enkephalin from its prohormone, proenkephalin A. Met enkephalin may be capable of enhancing immune function in cancer or AIDS patients. Enkephalin and enkephalin like peptides have been detected in many animal species. In mammals these opioid pentapeptides are cleaved from a common precursor molecule which is expressed in a number of cell types,including neurons and endocrine cells associated with the sympathetic nervous system where they are often costored with catecholamines. They are known to be endogenous ligands for delta-opioid receptors and are known to mediate analgesia at the spinal level. During development of the brain metenkephalin is thought to act as a growth factor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PENK
• Entrez:
  • 5179(Human)
• Uniprot:
  • P01210(Human)