PREX2 Antibody - BSA Free

Immunohistochemistry-Paraffin: PREX2 Antibody [NBP1-84275] - Staining of human small intestine shows moderate to strong membranous positivity in glandular cells.

Immunohistochemistry-Paraffin: PREX2 Antibody [NBP1-84275] - Staining of human colorectal cancer shows strong membranous positivity in tumor cells.

Immunohistochemistry-Paraffin: PREX2 Antibody [NBP1-84275] - Staining of human pancreas shows strong membranous positivity in a subset of exocrine glandular cells.

Immunohistochemistry-Paraffin: PREX2 Antibody [NBP1-84275] - Staining of human placenta shows strong membranous positivity in trophoblastic cells.

Immunohistochemistry-Paraffin: PREX2 Antibody [NBP1-84275] - Staining in human placenta and small intestine tissues . Corresponding PREX2 RNA-seq data are presented for the same tissues.

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

PREX2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: GLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNV
• Predicted Species: Mouse (94%), Rat (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PREX2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  PREX2 Protein (NBP1-84275PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for PREX2 Antibody - BSA Free

• DEP domain-containing protein 2
• DEP.2
• DEPDC2
• phosphatidylinositol 34,5-trisphosphate-dependent Rac exchanger 2 protein
• phosphatidylinositol-34,5-trisphosphate-dependent Rac exchange factor 2
• P-REX2,6230420N16Rik
• PtdIns(34,5)-dependent Rac exchanger 2

Background

PREX2 functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDPfor free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gammasubunits of heterotrimeric G

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PREX2 Antibody (NBP1-84275)(1)

Publication using NBP1-84275

• Huang Y, Xie Y et al. Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma. J Allergy Clin Immunol 2019-01-02 [PMID: 30312708] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: PREX2