Presenilin-2 Antibody (198C679.2.)

Western Blot: Presenilin-2 Antibody (198C679.2.) [NB100-56677] - Analysis for Presenilin-2 using this antibody. A protein band of approximate molecular weight of 55 kDa was detected.

Product Discontinued

Presenilin-2 Antibody (198C679.2.) Summary

• Immunogen: This antibody was generated by immunizing mice with a synthetic peptide of human Presenilin-2 (PS-2).
• Specificity: This tested negative in mouse NIH 3T3 cells.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: PSEN2
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1:250-1:500
• Control:

  Jurkat Whole Cell Lysate

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Tissue culture supernatant
• Preservative: 0.02% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for Presenilin-2 Antibody (198C679.2.)

• AD3LP
• AD4AD3L
• AD5
• E5-1
• EC 3.4.23
• EC 3.4.23.-
• presenilin 2 (Alzheimer disease 4)
• Presenilin2
• Presenilin-2
• PS-2
• PS2CMD1V
• PSEN2
• PSNL2
• STM2STM-2

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSEN2
• Entrez:
  • 5664(Human)
• Uniprot:
  • P49810()