Presenilin-2 Products

Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

Bioinformatics

Entrez	5664 Human 19165 Mouse 81751 Rat
Product By Gene ID	5664
Alternate Names	AD3LP AD4AD3L AD5 E5-1 EC 3.4.23 EC 3.4.23.- presenilin 2 (Alzheimer disease 4) Presenilin2 Presenilin-2 PS-2 PS2CMD1V PSEN2 PSNL2 STM2STM-2

Research Areas for Presenilin-2

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Neuroscience