Presenilin-2 Products

Antibodies
Lysates
Presenilin-2 Overexpression L ...
Presenilin-2 Overexpression Lysate...
NBP2-10350
Applications: WB
Proteins
Presenilin-2 Partial Recombin ...
Presenilin-2 Partial Recombinant P...
H00005664-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Presenilin-2 RNAi
Presenilin-2 RNAi
H00005664-R01
Species: Hu
Presenilin-2 RNAi
Presenilin-2 RNAi
H00005664-R02
Species: Hu

Description

Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5664
Alternate Names
  • EC 3.4.23
  • E5-1
  • PSNL2
  • AD5
  • EC 3.4.23.-
  • AD3LP
  • presenilin-2
  • AD4AD3L
  • PS2CMD1V
  • STM2STM-2
  • PS-2
  • presenilin 2 (Alzheimer disease 4)

Research Areas for Presenilin-2

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Neurodegeneration
Neuroscience
Phospho-Specific
Stem Cell Signaling Pathway

Bioinformatics Tool for Presenilin-2

Discover related pathways, diseases and genes to Presenilin-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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