Presenilin-1 Antibody (121130) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 121130
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Presenilin-1 Antibody (121130) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Presenilin‑1 N-Terminal Fragment
  Met1-Lys80
  Accession # P49768
• Specificity: Detects human Presenilin‑1 N-Terminal Fragment in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Presenilin-1 C-Terminal Fragment, rhPresenilin-2 C-Terminal Fragment, or rhPresenilin-2 N-Termin
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Presenilin-1 Antibody (121130) [Alexa Fluor® 700]

• AD3EC 3.4.23.-
• Alzheimer disease 3
• EC 3.4.23
• FAD
• presenilin 1
• Presenilin1
• Presenilin-1
• Protein S182
• PS-1
• PS1presenilin-1
• PSEN1
• PSNL1
• S182

Background

Presenilin‑1 (PS-1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N‑ and C‑terminal fragments. Some mutations in PS-1 are associated with the risk of early onset familial Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.