PPP2R2B Antibody

Western Blot: PPP2R2B Antibody [NBP1-33043] - Sample (30 ug of whole cell lysate) A: Hep G2 10% SDS PAGE; antibody diluted at 1:1000.

Immunohistochemistry-Paraffin: PPP2R2B Antibody [NBP1-33043] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution.

Western Blot: PPP2R2B Antibody [NBP1-33043] - Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE, antibody diluted at 1:3000.

Product Discontinued

PPP2R2B Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human PPP2R2B. The exact sequence is proprietary.
• Predicted Species: Xenopus (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PPP2R2B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Xenopus laevis (94%), Xenopus tropicalis (94%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for PPP2R2B Antibody

• B55BETA
• FLJ95686
• MGC24888
• PP2A subunit B isoform B55-beta
• PP2A subunit B isoform beta
• PP2A subunit B isoform PR55-beta
• PP2A subunit B isoform R2-beta
• PP2A, subunit B, B-beta isoform
• PP2AB55BETA
• PP2ABBETA
• PP2APR55B
• PP2APR55BETA
• PR2AB55BETA
• PR2ABBETA
• PR2APR55BETA
• PR52B
• PR55BETA
• PR55-BETA
• protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
• protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
• protein phosphatase 2, regulatory subunit B, beta
• SCA12
• serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, betaisoform
• serine/threonine protein phosphatase 2A, neuronal isoform
• serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B betaisoform
• spinocerebellar ataxia 12

Background

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: PPP2R2B
• Entrez:
  • 5521(Human)
  • 72930(Mouse)
• Uniprot:
  • Q00005(Human)