PPP1R3C Antibody

Product Discontinued

PPP1R3C Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 40-93 of Human PTG.
• Specificity: PTG detects endogenous levels of PPP1R3C protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PPP1R3C
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of PTG pAb in extracts from HepG2 cells.
• Theoretical MW: 36 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PPP1R3C Antibody

• Phosphatase 1, regulatory inhibitor subunit 5
• PPP1R5PP1 subunit R5
• protein phosphatase 1 regulatory subunit 3C
• Protein phosphatase 1 regulatory subunit 5
• protein phosphatase 1, regulatory (inhibitor) subunit 3C
• Protein targeting to glycogen
• PTG

Background

Protein phosphatase 1 (PP1) is a serine-threonine protein phosphatase that plays a central role in mediating the effects of insulin on glucose and lipid metabolism. PTG (protein targeting to glycogen) was cloned from 3T3-L1 adipocytes as a protein that binds to the PP1 catalytic subunit. The human homolog of PTG, designated PPP1R5, has been shown to bind to PP1 and to modulate its specificity. PTEN/PPP1R5 shows 42% identity to the glycogen binding subunit, G(L), of rat liver PP1. PTG is expressed predominantly in insulin-sensitive tissues, and it localizes PP1 to glycogen. PTG also has been shown to interact with several enzymes involved in the hormonal regulation of glycogen metabolism, including phosphorylase kinase, phosphorylase A and glycogen synthase. These data indicate a role for PTG in glycogen metabolism, possibly that of a molecular scaffold.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPP1R3C
• Entrez:
  • 5507(Human)