Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Immunogen affinity purified
Manufactured by SDIX's proprietary Genomic Antibody Technology. GAT FAQs.
Alternate Names for PPM1D Antibody
p53-induced protein phosphatase 1
protein phosphatase 1D magnesium-dependent, delta isoform
protein phosphatase 1D
protein phosphatase 2C delta isoform
Protein phosphatase 2C isoform delta
Protein phosphatase magnesium-dependent 1 delta
protein phosphatase, Mg2+/Mn2+ dependent, 1D
wild-type p53-induced phosphatase 1
WIP1protein phosphatase Wip1
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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