PPM1D Products

Antibodies
PPM1D Antibody
PPM1D Antibody
NB100-2110
Species: Hu, Primate, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
PPM1D Antibody
PPM1D Antibody
NBP1-87249
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PPM1D Antibody (4D1)
PPM1D Antibody (4D1)
H00008493-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Proteins
PPM1D Recombinant Protein Ant ...
PPM1D Recombinant Protein Antigen
NBP1-87249PEP
Species: Hu
Applications: AC
PPM1D Recombinant Protein
PPM1D Recombinant Protein
NBP2-51998
Species: Hu
Applications: PAGE
RNAi
PPM1D RNAi
PPM1D RNAi
H00008493-R02
Species: Hu

Description

PPM1D is encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 8493
Alternate Names
  • Protein phosphatase 2C isoform delta
  • protein phosphatase 1D
  • p53-induced protein phosphatase 1
  • Wip1
  • PP2C-delta
  • Protein phosphatase magnesium-dependent 1 delta
  • EC 3.1.3.16
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • wild-type p53-induced phosphatase 1
  • PP2C-DELTA
  • WIP1protein phosphatase Wip1
  • protein phosphatase 2C delta isoform
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D

Research Areas for PPM1D

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

PTMs for PPM1D

Learn more about PTMs related to PPM1D.

Phosphorylation
Dephosphorylation
Ubiquitination
Cleavage
Methylation

Bioinformatics Tool for PPM1D

Discover related pathways, diseases and genes to PPM1D. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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