Polycystin-1/PKD1 Antibody [Allophycocyanin]

• Reactivity: Hu
• Applications: ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Allophycocyanin

Polycystin-1/PKD1 Antibody [Allophycocyanin] Summary

• Immunogen: E. coli-derived recombinant human Polycystin-1/PKD1
  Gly4142-Thr4303
  Accession # P98161
• Specificity: Detects human Polycystin-1/PKD1 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PKD1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for Polycystin-1/PKD1 Antibody [Allophycocyanin]

• Autosomal dominant polycystic kidney disease 1 protein
• PBP
• Pc-1
• PKD1
• polycystic kidney disease 1 (autosomal dominant)
• polycystic kidney disease-associated protein
• polycystin 1
• Polycystin1
• Polycystin-1
• transient receptor potential cation channel, subfamily P, member 1
• TRPP1

Background

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoforms (delta, episilon , zeta, eta and theta). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and episilon are independent of Ca++. On the other hand, nPKC delta and episilon, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PKD1