PLK3 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 750

PLK3 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human PLK3
  Pro320-Ala520
  Accession # Q9H4B4.2
• Specificity: Detects human PLK3 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PLK3 Antibody [Alexa Fluor® 750]

• CNK
• CNKpolo-like kinase 3 (Drosophila)
• cytokine-inducible kinase
• Cytokine-inducible serine/threonine-protein kinase
• EC 2.7.11
• FNK
• FNKEC 2.7.11.21
• PLK3
• polo-like kinase 3PLK-3
• PRK
• PRKFGF-inducible kinase
• Proliferation-related kinase
• serine/threonine-protein kinase PLK3

Background

Polo-like kinases are critical regulators of cell cycle progression, cytokinesis, mitosis, and the genotoxic stress response. Four distinct members have been identified to date in mammalian cells: PLK1, PLK2, PLK3, and PLK4. PLK3 (polo-like kinase 3) plays an important role in cell cycle regulation by modulating microtubule dynamics and centrosomal function. Although protein levels are unchanged throughout the cell cycle, kinase activity peaks during late S and G2 phases. Many key cell cycle regulators are phosphorylated by PLK3 including p53 on Ser20, Cdc25C on Ser216, and the major subunit of DNA polymerase δ, p125 on Ser60.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.