Plexin C1 Antibody (544232) [DyLight 350]

• Reactivity: Hu, Mu
• Applications: Flow, IHC, B/N
• Clone: 544232
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 350

Plexin C1 Antibody (544232) [DyLight 350] Summary

• Immunogen: E. coli-derived recombinant human Plexin C1
  Ile49-Ser161
  Accession # O60486
• Specificity: Detects human Plexin C1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Plexin A4, B1, B2, B3, D1, recombinant mouse Plexin A1, A2, or A3 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PLXNC1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Neutralization
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Plexin C1 Antibody (544232) [DyLight 350]

• CD232 antigen
• CD232
• plexin (semaphorin receptor)
• Plexin C1
• PLXNC1
• PLXN-C1
• receptor for viral semaphorin protein
• receptor for virally-encoded semaphorin
• VESPR
• VESPRplexin-C1
• Virus-encoded semaphorin protein receptor

Background

Plexin C1, also known by its gene name PLXNC1, is approximately 176kDa and 1,568 amino acids in length. Plexin C1 is localized to the cellular membrane as a transmembrane receptor for the Semaphorins family of proteins. Plexin C1 may be implicated in the regulation of melanocyte adhesion and may be a melanoma tumor suppressor. Current research on Plexin C1 is being performed in relation to several diseases and disorders including Parkinson's disease, leukemia, kidney disease, melanoma, smallpox, prostate cancer, malignant glioma, renal cell carcinoma, ovarian cancer, pancreatic cancer, hepatitis, prostatitis, and pancreatitis. Plexin C1 has also been shown to have interactions with SEMA7A in the axon guidance pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PLXNC1