PIEZO1 Antibody [DyLight 650]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.

PIEZO1 Antibody [DyLight 650] Summary

A synthetic peptide made to an internal portion of the human PIEZO1 protein (between residues 950-1000) [UniProt Q92508]
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 650
DyLight 650 (A=652, E=672)
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:25
  • Immunohistochemistry 1:400
  • Immunohistochemistry-Paraffin 1:400
Application Notes
This PIEZO1 antibody is useful for Immunocytochemistry/Immunofluorescence, and IHC-paraffin embedded sections. In Western Blot, a band is seen ~286 kDa representing PIEZO1 protein. In ICC/IF, membrane staining is observed in A431 cells. In IHC-P, membrane and cytoplasmic staining is seen in mouse epidermis tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse.

Alternate Names for PIEZO1 Antibody [DyLight 650]

  • FAM38A
  • member A
  • membrane protein induced by beta-amyloid treatment
  • Mib
  • piezo-type mechanosensitive ion channel component 1


Piezo1 (Mib, FAM38A) is a mechanosensitive ion channel which responds to mechanically activated currents in numerous cells, including the brain, bladder, colon, kidney, lung, and skin. However, mRNA expression of Piezo1 is weak in the DRG, unlike Piezo2. The expression of Piezo1 is induced in Alzheimer's associated senile plaques (PMID 16854388), as well as integrin activation through R-Ras signaling (PMID 20016066). R-Ras is recruited to the endoplasmic reticulum which increases calcium release, leading to the activation of the protease calpain. Piezo proteins are fairly novel proteins, and whose sequences are not akin to other ion channels or proteins.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for PIEZO1 Antibody (NBP1-78446C) (0)

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Secondary Antibodies


Isotype Controls

Additional PIEZO1 Antibody [DyLight 650] Products

PIEZO1 NBP1-78446C

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Bioinformatics Tool for PIEZO1 Antibody (NBP1-78446C)

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Diseases for PIEZO1 Antibody (NBP1-78446C)

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Research Areas for PIEZO1 Antibody (NBP1-78446C)

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Blogs on PIEZO1.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

PIEZO1: A Mechanosensitive Ion Channel Protein
PIEZO1, and its close homologue PIEZO2, are mechanosensitive ion channel proteins. Mechanosensitive ion channels couple protein conformation to the mechanics of the surrounding membrane, and switch between a closed state and an open state in response...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol PIEZO1

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