PIEZO1 Antibody [DyLight 650]


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Product Details

Reactivity Hu, Mu, GpSpecies Glossary
Applications Flow, ICC/IF, IHC, IHC-P
DyLight 650

PIEZO1 Antibody [DyLight 650] Summary

A synthetic peptide made to an internal portion of the human PIEZO1 protein (between residues 950-1000) [UniProt Q92508]
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein.
Immunogen affinity purified
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  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This PIEZO1 antibody is useful for Immunocytochemistry/Immunofluorescence, and IHC-paraffin embedded sections. In ICC/IF, membrane staining is observed in A431 cells. In IHC-P, membrane and cytoplasmic staining is seen in mouse epidermis tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Guinea Pig reactivity reported in scientific literature (PMID: 30324494).

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PIEZO1 Antibody [DyLight 650]

  • FAM38A
  • member A
  • membrane protein induced by beta-amyloid treatment
  • Mib
  • piezo-type mechanosensitive ion channel component 1


Piezo1 (Mib, FAM38A) is a mechanosensitive ion channel which responds to mechanically activated currents in numerous cells, including the brain, bladder, colon, kidney, lung, and skin. However, mRNA expression of Piezo1 is weak in the DRG, unlike Piezo2. The expression of Piezo1 is induced in Alzheimer's associated senile plaques (PMID 16854388), as well as integrin activation through R-Ras signaling (PMID 20016066). R-Ras is recruited to the endoplasmic reticulum which increases calcium release, leading to the activation of the protease calpain. Piezo proteins are fairly novel proteins, and whose sequences are not akin to other ion channels or proteins.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for PIEZO1 Antibody (NBP1-78446C) (0)

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-78446AF350
Alexa Fluor 405 NBP1-78446AF405
Alexa Fluor 488 NBP1-78446AF488
Alexa Fluor 532 NBP1-78446AF532
Alexa Fluor 594 NBP1-78446AF594
Alexa Fluor 647 NBP1-78446AF647
Alexa Fluor 700 NBP1-78446AF700
Alexa Fluor 750 NBP1-78446AF750
Biotin NBP1-78446B
DyLight 350 NBP1-78446UV
DyLight 405 NBP1-78446V
DyLight 488 NBP1-78446G
DyLight 550 NBP1-78446R
DyLight 594 NBP1-78446DL594
DyLight 650 NBP1-78446C
DyLight 680 NBP1-78446FR
DyLight 755 NBP1-78446IR
FITC NBP1-78446F
HRP NBP1-78446H
Janelia Fluor 549 NBP1-78446JF549
Janelia Fluor 646 NBP1-78446JF646

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Bioinformatics Tool for PIEZO1 Antibody (NBP1-78446C)

Discover related pathways, diseases and genes to PIEZO1 Antibody (NBP1-78446C). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for PIEZO1 Antibody (NBP1-78446C)

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Blogs on PIEZO1.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

PIEZO1: A Mechanosensitive Ion Channel Protein
PIEZO1, and its close homologue PIEZO2, are mechanosensitive ion channel proteins. Mechanosensitive ion channels couple protein conformation to the mechanics of the surrounding membrane, and switch between a closed state and an open state in response...  Read full blog post.

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Gene Symbol PIEZO1