PHOX2B Antibody

Product Discontinued

PHOX2B Antibody Summary

• Immunogen: Peptide with sequence C-SRDDESKEAKSTDP corresponding to internal region according to NP_003915.2.
• Epitope: C terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PHOX2B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in human brain (cerebellum) lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for PHOX2B Antibody

• NBPhox
• NBPhoxPhox2b
• Neuroblastoma Phox
• paired mesoderm homeobox 2b
• paired mesoderm homeobox protein 2B
• paired-like homeobox 2bNBLST2
• PHOX2B homeodomain protein
• PHOX2B
• PMX2B
• PMX2Bneuroblastoma paired-type homeobox protein

Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PHOX2B Antibody (NBP1-28488)(1)

Publication using NBP1-28488

• McGaughey DM, Vinton RM, Huynh J et al. Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome Res 2008-02-01 [PMID: 18071029]

Bioinformatics

• Gene Symbol: PHOX2B
• Entrez:
  • 8929(Human)
  • 18935(Mouse)
• Uniprot:
  • NP_003915.2(Human)