PHLPP2 Antibody - BSA Free

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Immunohistochemistry: PHLPP2 Antibody [NBP3-30962] - Immunohistochemical staining of normal human kidney tissue using PHLPP2 antibody (Cat. No. NBP3-30962) at 15 ug/ml and detected using anti-Rabbit HRP secondary ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free

Order Details

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Catalog# & Formulation Size Price

PHLPP2 Antibody - BSA Free Summary

Immunogen
Synthetic peptide derived from the human PHLPP2 protein
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PHLPP2
Purity
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry-Paraffin : 10-15 ug/ml
  • Western Blot
Application Notes
.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline
Preservative
0.08% Sodium Azide
Purity
Antigen Affinity-purified

Alternate Names for PHLPP2 Antibody - BSA Free

  • EC 3.1.3.16
  • KIAA0931PH domain leucine-rich repeat-containing protein phosphatase 2
  • PH domain and leucine rich repeat protein phosphatase 2
  • PH domain and leucine rich repeat protein phosphatase-like
  • PH domain leucine-rich repeat-containing protein phosphatase-like
  • PHLPPLPHLPP-like

Background

PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PHLPP2