PHLPP2 Products

Description

PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.

Bioinformatics

Uniprot	NP_055835 Human NP_055835.2 Human Q6ZVD8 Human
Product By Gene ID	23035
Alternate Names	EC 3.1.3.16 KIAA0931PH domain leucine-rich repeat-containing protein phosphatase 2 PH domain and leucine rich repeat protein phosphatase 2 PH domain and leucine rich repeat protein phosphatase-like PH domain leucine-rich repeat-containing protein phosphatase-like PHLPPLPHLPP-like

Research Areas for PHLPP2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors