PHLPP2 Products

Antibodies
PHLPP2 Antibody
PHLPP2 Antibody
NB100-1812
Species: Hu, Mu, Rt, Guinea Pig, Primate, Rabbit, Squirrel, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
PHLPP2 Antibody
PHLPP2 Antibody
NBP2-13757
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PHLPP2 Antibody
PHLPP2 Antibody
NBP2-19803
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
PHLPP2 Overexpression Lysate ...
PHLPP2 Overexpression Lysate (Native)
NBP2-07231
Applications: WB
Proteins
PHLPP2 Recombinant Protein An ...
PHLPP2 Recombinant Protein Antigen
NBP2-13757PEP
Species: Hu
Applications: AC
RNAi
PHLPP2 RNAi
PHLPP2 RNAi
H00023035-R01
Species: Hu

Description

PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 23035
Alternate Names
  • PH domain leucine-rich repeat-containing protein phosphatase-like
  • EC 3.1.3.16
  • PHLPPLPHLPP-like
  • KIAA0931PH domain leucine-rich repeat-containing protein phosphatase 2
  • PH domain and leucine rich repeat protein phosphatase-like
  • PH domain and leucine rich repeat protein phosphatase 2

Pathways for PHLPP2

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
Translation
Cell Death
Cell Growth
Localization
Transport
Glucose Transport

Research Areas for PHLPP2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors

PTMs for PHLPP2

Learn more about PTMs related to PHLPP2.

Phosphorylation
Dephosphorylation

Bioinformatics Tool for PHLPP2

Discover related pathways, diseases and genes to PHLPP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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