PGLYRP4/PGRP-I beta Antibody [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: mFluor Violet 610 SE

PGLYRP4/PGRP-I beta Antibody [mFluor Violet 610 SE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PGLYRP4/PGRP-I beta
  Asp18-Lys372
  Accession # Q96LB8
• Specificity: Detects human PGLYRP4/PGRP-I beta in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross‑reactivity with recombinant mouse PGRP-I beta is observed and 10% cross-reactivity with recombinant human PGRP-S is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PGLYRP4
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PGLYRP4/PGRP-I beta Antibody [mFluor Violet 610 SE]

• peptidoglycan recognition protein 4
• peptidoglycan recognition protein I beta
• Pglyrp-1 beta
• PGLYRP4
• PGRPI beta
• PGRP-I beta
• PGRP-I-beta

Background

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-I alpha, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PGLYRP4