PGLYRP4/PGRP-I beta Antibody (474034) [Alexa Fluor® 350]

• Applications: WB, IP
• Clone: 474034
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

PGLYRP4/PGRP-I beta Antibody (474034) [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PGLYRP4/PGRP-Iβ
  Asp18-His373
  Accession # Q96LB8
• Specificity: Detects human PGLYRP4/PGRP-I beta in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse PGRP-I beta or recombinant human PGRP-S is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Peptidoglycan recognition protein intermediate beta (PGRP-I beta ), also known as peptidoglycan recognition protein 4 (PGLRP4), belongs to the family of human recognition molecules that bind peptidoglycan (a ubiquitous component of bacterial cell walls) and gram-positive bacteria as part of the innate immune response. It has N-acetylmuramoyl-L-alanine amidase activity and is primarily expressed in the esophagus, where it is thought to play a role in host antimicrobial defense. PGRP-I beta has two predicted transmembrane domains and extracellular N- and C-termini. The amino acid sequence of human PGRP- I beta is 99% and 76% identical to that of chimpanzee and mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.