PGLYRP3/PGRPIA Antibody

Western Blot: PGLYRP3/PGRPIA Antibody [NBP1-80919] - PGRP1A Antibody [NBP1-80919] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4.

Immunohistochemistry-Paraffin: PGRP1A Antibody [NBP1-80919] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Product Discontinued

PGLYRP3/PGRPIA Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: PAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPNIIKRSAWEARETHCPK
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PGLYRP3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for PGLYRP3/PGRPIA Antibody

• peptidoglycan recognition protein 3
• peptidoglycan recognition protein I alpha
• Peptidoglycan recognition protein I-alpha
• Peptidoglycan recognition protein intermediate alpha
• peptidoglycan recognition protein-I-alpha
• PGLYRP3
• PGLYRPIalphaMGC149197
• PGRP1A
• PGRPI alpha
• PGRP-I alpha
• PGRPIA
• PGRP-Ialpha
• PGRPIAPGRP-I-alpha

Background

Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia , and PGRP-I

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PGLYRP3
• Entrez:
  • 114771(Human)
• Uniprot:
  • Q96LB9()
  • Q96LB9()
  • Q96LB9()
  • Q96LB9()