PERK Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, KO
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 750

PERK Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human PERK
  Ala29-Gln230
  Accession # Q9NZJ5
• Specificity: Detects human PERK in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Knockout Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PERK Antibody [Alexa Fluor® 750]

• DKFZp781H1925
• EC 2.7.11.1
• EIF2AK3
• eukaryotic translation initiation factor 2 alpha kinase 3
• eukaryotic translation initiation factor 2-alpha kinase 3
• hsPEK
• PEK
• PEKPERKPancreatic eIF2-alpha kinase
• PERK
• PRKR-like endoplasmic reticulum kinase
• WRS

Background

PERK, a type 1 ER membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism. Phosphorylation of eIF2 alpha also selectively promotes the expression of UPR target genes such as Chop and BiP. PERK may also play a role in tumor cell adaptation to hypoxic stress by regulating the translation of angiogenic factors necessary for the development of functional microvessels. Mutations in PERK are responsible for the rare autosomal-recessive disorder, WRS (Wolcott-Rallison syndrome).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.