PERK Products

Antibodies
PERK Antibody
PERK Antibody
NBP1-78017
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
PERK Antibody [Unconjugated]
PERK Antibody [Unconjugated]
AF3999
Species: Hu
Applications: WB
Host: Goat Polyclonal
PERK Antibody
PERK Antibody
NB100-92406
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
PERK Overexpression Lysate (N ...
PERK Overexpression Lysate (Native)
NBL1-10177
Applications: WB
Proteins
PERK Partial Recombinant Prot ...
PERK Partial Recombinant Protein
H00009451-Q01
Species: Hu
Applications: WB, ELISA, PA
PERK Recombinant Protein Anti ...
PERK Recombinant Protein Antigen
NBP1-80930PEP
Species: Hu
Applications: AC
RNAi
PERK RNAi
PERK RNAi
H00009451-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK 1 and Threonine 185 and Tyrosine 187 residues of ERK 2 is required for full enzymatic activation. The structural consequences of dual phosphorylation in ERK 2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Bioinformatics

Uniprot Human
Human
Human
Mouse
Product By Gene ID 9451
Alternate Names
  • WRS
  • HsPEK
  • EC 2.7.11.1
  • hsPEK
  • PRKR-like endoplasmic reticulum kinase
  • eukaryotic translation initiation factor 2 alpha kinase 3
  • PEKPERKPancreatic eIF2-alpha kinase
  • DKFZp781H1925
  • eukaryotic translation initiation factor 2-alpha kinase 3

Research Areas for PERK

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

PTMs for PERK

Learn more about PTMs related to PERK.

Phosphorylation
Oxidation

Bioinformatics Tool for PERK

Discover related pathways, diseases and genes to PERK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related PERK Blog Posts

Check out the latest blog posts on PERK.
eIF2alpha - a regulator of global translation in response to cellular stress
Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...    Read more.
Read more PERK related blogs.