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PERK Products

PERK Antibody [Unconjugated]
PERK Antibody [Unconjugated]
Species: Hu
Applications: WB, KO
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
PERK Antibody
PERK Antibody
Species: Hu, Ch
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
PERK Antibody
PERK Antibody
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IP, KO
Host: Rabbit Polyclonal
PERK Overexpression Lysate
PERK Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human PERK GST (N ...
Recombinant Human PERK GST (N-Term...
Species: Hu
Applications: WB, ELISA, MA, AP
PERK Recombinant Protein Anti ...
PERK Recombinant Protein Antigen
Species: Hu
Applications: AC


The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK 1 and Threonine 185 and Tyrosine 187 residues of ERK 2 is required for full enzymatic activation. The structural consequences of dual phosphorylation in ERK 2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.


Uniprot Human
Product By Gene ID 9451
Alternate Names
  • DKFZp781H1925
  • EC
  • eukaryotic translation initiation factor 2 alpha kinase 3
  • eukaryotic translation initiation factor 2-alpha kinase 3
  • hsPEK
  • HsPEK
  • PEKPERKPancreatic eIF2-alpha kinase
  • PRKR-like endoplasmic reticulum kinase
  • WRS

Research Areas for PERK

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

Related PERK Blog Posts

Check out the latest blog posts on PERK.
eIF2alpha - a regulator of global translation in response to cellular stress
Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...    Read more.
Read more PERK related blogs.