Perilipin-3/TIP47 Antibody

Product Discontinued

Perilipin-3/TIP47 Antibody Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TIP47. The immunogen is located within the last 50 amino acids of TIP47.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PLIN3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Perilipin-3/TIP47 Antibody

• Cargo selection protein TIP47
• M6PRBP1
• M6PRBP1MGC2012
• Mannose-6-phosphate receptor-binding protein 1
• perilipin 3,47 kDa MPR-binding protein
• Perilipin3
• Perilipin-3
• Placental protein 17,47 kDa mannose 6-phosphate receptor-binding protein
• PLIN3
• PP17
• PP17MGC11117
• tail-interacting protein, 47 kD
• TIP47
• TIP47mannose-6-phosphate receptor binding protein 1

Background

Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PLIN3
• Uniprot:
  • O60664(Human)