Perilipin-3/TIP47 Antibody (779103) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 779103
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Perilipin-3/TIP47 Antibody (779103) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Perilipin‑3
  Met1-Lys434
  Accession # O60664
• Specificity: Detects human Perilipin‑3 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) Perilipin-2 or rhPerilipin-5 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Perilipin-3/TIP47 Antibody (779103) [Alexa Fluor® 700]

• Cargo selection protein TIP47
• M6PRBP1
• M6PRBP1MGC2012
• Mannose-6-phosphate receptor-binding protein 1
• perilipin 3,47 kDa MPR-binding protein
• Perilipin3
• Perilipin-3
• Placental protein 17,47 kDa mannose 6-phosphate receptor-binding protein
• PLIN3
• PP17
• PP17MGC11117
• tail-interacting protein, 47 kD
• TIP47
• TIP47mannose-6-phosphate receptor binding protein 1

Background

M6PRBP1 (mannose 6-phosphate receptor binding protein), gene name PLIN3 (Perilipin-3), also called TIP47 (tail interacting protein of 47 kDa) or PP17 (placental protein 17), is a 47 kDa intracellular transport protein that belongs to the PAT (Perilipin/Adipophilin/TIP47) family of molecules. The 434 amino acid (aa) human Perilipin‑3, which shares approximately 75% aa sequence identity with mouse and rat Perilipin-3, contains a four-helix bundle thought to interact with membranes, and may be phosphorylated and acetylated. A 251 aa form (isoform A) has an alternate start site at aa 184 of the 434 aa form (isoform B). Perilipin-3 is normally found predominantly in the cytoplasm. It is required for uptake of mannose-6 phosphate receptors into endosomes. In the presence of excess lipids, such as in macrophage-derived foam cells, Perilipin-3 may transfer free fatty acids to lipid droplets, promoting their growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.