PDE11A Antibody

Immunohistochemistry-Paraffin: PDE1C Antibody [NB110-40468] - Analysis of anti-PDE11A antibody with human testis at concentration 5 ug/ml.

Product Discontinued

PDE11A Antibody Summary

• Immunogen: Synthetic 17 amino acid peptide from internal region of human PDE11A.
• Epitope: internal domain of human
• Specificity: Human PDE11A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PDE6B (53%).
• Predicted Species: Turkey (100%), Xenopus (94%), Opossum (100%), Fish (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PDE11A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Canine (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 0.23 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PDE11A Antibody

• cAMP and cGMP cyclic nucleotide phosphodiesterase 11A
• cAMP and cGMP phosphodiesterase 11A
• cyclic nucleotide phosphodiesterase 11A
• dual 3'-5'-cyclic-AMP and -GMP phosphodiesterase 11A
• EC 3.1.4
• EC 3.1.4.17
• EC 3.1.4.35
• EC 3.1.4.53
• FLJ23693
• MGC133355
• MGC133356
• PDE11A
• PDE11A1
• PDE11A2
• PDE11A3
• phosphodiesterase 11A
• PPNAD2

Background

One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDE11A
• Entrez:
  • 50940(Human)
• Uniprot:
  • Q9HCR9(Human)