PDE11A Products

Description

One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.

Bioinformatics

Entrez	50940 Human
Uniprot	Q9HCR9 Human
Product By Gene ID	50940
Alternate Names	cAMP and cGMP cyclic nucleotide phosphodiesterase 11A cAMP and cGMP phosphodiesterase 11A cyclic nucleotide phosphodiesterase 11A dual 3'-5'-cyclic-AMP and -GMP phosphodiesterase 11A EC 3.1.4 EC 3.1.4.17 EC 3.1.4.35 EC 3.1.4.53 FLJ23693 MGC133355 MGC133356 PDE11A PDE11A1 PDE11A2 PDE11A3 phosphodiesterase 11A PPNAD2

Research Areas for PDE11A

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Signal Transduction