Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Bioinformatics
Uniprot |
Human Human Human Human Human Human Human |
Product By Gene ID |
50940 |
Alternate Names |
- cAMP and cGMP cyclic nucleotide phosphodiesterase 11A
- cAMP and cGMP phosphodiesterase 11A
- cyclic nucleotide phosphodiesterase 11A
- dual 3'-5'-cyclic-AMP and -GMP phosphodiesterase 11A
- EC 3.1.4
- EC 3.1.4.17
- EC 3.1.4.35
- FLJ23693
- MGC133355
- MGC133356
- PDE11A1
- PDE11A2
- PDE11A3
- phosphodiesterase 11A
- PPNAD2
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Research Areas for PDE11A
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction