PDE11A Products

Description

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Uniprot	Q9HCR9 Human NP_001070826.1 Human NP_001070664.1 Human NP_001070665.1 Human NP_058649 Human NP_058649.3 Human NP_058649.3 Human
Product By Gene ID	50940
Alternate Names	EC 3.1.4 PDE11A3 MGC133356 PDE11A2 MGC133355 PDE11A1 FLJ23693 EC 3.1.4.17 PPNAD2 dual 3'-5'-cyclic-AMP and -GMP phosphodiesterase 11A EC 3.1.4.35 cyclic nucleotide phosphodiesterase 11A cAMP and cGMP phosphodiesterase 11A cAMP and cGMP cyclic nucleotide phosphodiesterase 11A phosphodiesterase 11A

Diseases related to PDE11A

Discover more about diseases related to PDE11A.

Neoplasms
Hyperplasia
Cushing Syndrome
Adenoma
Tumors Of Adrenal Cortex
Carney Complex
Adrenal Hyperplasia
Malignant Neoplasms
Adrenal Cortex Diseases
Depressive Disorder
Adrenal Cortical Hyperplasia
Carcinoma
Adrenal Cortical Adenoma
Cell Transformation, Neoplastic
Testicular Neoplasms
Pituitary Diseases
Major Depressive Disorder
Testicular Germ Cell Tumor
Pigmentation Disorders
Multiple Endocrine Neoplasia

Pathways for PDE11A

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Secretion
Pathogenesis
Pigmentation
Cortisol Secretion
Localization
Cellular Response To Dsrna
Transport
Protein Phosphorylation
Fertilization
Spermatogenesis
Cell Cycle
Cell Differentiation
Dsrna Fragmentation
Catabolic Process
Hormone Secretion
Transmembrane Transport
Insulin Secretion
Response To Dsrna
Methylation
Erbb Signaling Pathway

Research Areas for PDE11A

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Signal Transduction

PTMs for PDE11A

Learn more about PTMs related to PDE11A.

Phosphorylation
Methylation

Bioinformatics Tool for PDE11A

Discover related pathways, diseases and genes to PDE11A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.