p38 alpha [p Thr180, p Tyr182] Antibody (948243) [Unconjugated]

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p38 alpha phosphorylated at T180/Y182 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line, untreated or treated with calf intestinal phosphatase, using Rat Anti-Human Phospho-p38 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clone
948243
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

p38 alpha [p Thr180, p Tyr182] Antibody (948243) [Unconjugated] Summary

Immunogen
Phosphopeptide containing human p38 alpha T180/Y182 site
Accession # Q16539
Modification
p Thr180, p Tyr182
Specificity
Detects human p38 alpha when phosphorylated at T180/Y182.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
MAPK14
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry 5-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for p38 alpha [p Thr180, p Tyr182] Antibody (948243) [Unconjugated]

  • MAPK14
  • p38 alpha
  • SAPK2a

Background

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses, such as UV irradiation and heat shock. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). p38 MAPK is involved in the regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, and indirectly CREB via activation of MSK1. The p38 MAPK protein also plays a role in cell differentiation, autophagy and apoptosis. Mkk3 and SEK can activate p38 MAPK by phosphorylation at Thr180 and Tyr182, which in turn activates the MAPKAP kinase 2 and regulating phosphorylation of ATF2, Mac and MEF2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MAPK14
Uniprot