OX40 Ligand/TNFSF4 Antibody (159403) [Phycoerythrin]

Images

 
Human peripheral blood mononuclear cells (PBMCs) treated with Recombinant Human GM‑CSF (Catalog # 215-GM) and LPS for 48 hours were stained with Mouse Anti-Human OX40 Ligand/TNFSF4 PE‑conjugated Monoclonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
159403
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

OX40 Ligand/TNFSF4 Antibody (159403) [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human OX40 Ligand
Gln51-Leu183
Accession # P23510
Specificity
Detects human OX40 Ligand in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) APRIL, rhBAFF, rhCD27 Ligand, recombinant mouse (rm) CD27 Ligand, rhCD30 Ligand, rmCD30 Ligand, rhCD40 Ligand, rmEDA, rhFas Ligand, rmFas Ligand, rhGITR Ligand, recombinant cotton rat TNF-alpha, rhTNF-alpha, rmTNF-alpha, recombinant porcine TNF-alpha, recombinant rat TNF-alpha, rhTRAIL, rhTRANCE, rmTRANCE, or rhVEGF is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFSF4
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB10541P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OX40 Ligand/TNFSF4 Antibody (159403) [Phycoerythrin]

  • CD134 ligand
  • CD134L
  • CD252 antigen
  • CD252
  • Glycoprotein Gp34
  • gp34
  • OX40 antigen ligand
  • OX40 Ligand
  • OX40L
  • OX-40L
  • OX4OL
  • TAX transcriptionally-activated glycoprotein 1
  • tax-transcriptionally activated glycoprotein 1 (34kD)
  • tax-transcriptionally activated glycoprotein 1, 34kD
  • TNFSF4
  • tumor necrosis factor (ligand) superfamily, member 4
  • tumor necrosis factor ligand superfamily member 4
  • TXGP1

Background

OX40 Ligand (OX40L), also known as gp34, is a type II transmembrane glycoprotein designated TNFSF4 within the TNF superfamily. Human OX40L cDNA encodes a 183 amino acids (aa) polypeptide with an amino-terminal cytoplasmic domain (aa 1-23) and a carboxy-terminal extracellular domain (aa 51-183). It shares 46% aa sequence identity with the mouse counterpart. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. Like other TNF superfamily members, membrane-bound OX40 Ligand exists as a homotrimer. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40 Ligand is one of the group of co-stimulatory molecules in the immune system that includes B7, CD40 Ligand, CD30 Ligand, CD27 Ligand and 4-1BB Ligand. OX40 appears as a late activation-induced T cell surface antigen, and its major function of OX40-OX40L interaction may be to transmit a late co-stimulatory signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. Engagement of OX40 on activated T cells in situ in tumors has been shown to augment immune responses and subsequent tumor regression.

  1. Godfrey, W.R. et al. (1994) J. Exp. Med. 180:757.
  2. Baum, P.R. et al. (1994) EMBO J. 13:3992.
  3. Al-Shamkhani, A. et al. (1997) J. Biol. Chem. 272:5275.
  4. Kjaergaard, J. et al. (2000) Cancer Res. 60:5514.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF3388
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
AF382
Species: Hu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, Neut
AF2295
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
NBP2-25255
Species: Hu, Mu
Applications: WB, Flow, IHC, IHC-P
AF1028
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
DDX0131P-100
Species: Hu
Applications: Flow, Func, ICC/IF, IHC, IHC-Fr, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
NBP2-45041
Species: Hu, Po
Applications: Flow, IHC, IHC-Fr, IF
NBP1-49045
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, CyTOF-ready, InhibTFunc

Publications for OX40 Ligand/TNFSF4 Antibody (FAB10541P)(2)

Reviews for OX40 Ligand/TNFSF4 Antibody (FAB10541P) (0)

There are no reviews for OX40 Ligand/TNFSF4 Antibody (FAB10541P). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for OX40 Ligand/TNFSF4 Antibody (FAB10541P) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional OX40 Ligand/TNFSF4 Products

Bioinformatics Tool for OX40 Ligand/TNFSF4 Antibody (FAB10541P)

Discover related pathways, diseases and genes to OX40 Ligand/TNFSF4 Antibody (FAB10541P). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for OX40 Ligand/TNFSF4 Antibody (FAB10541P)

Discover more about diseases related to OX40 Ligand/TNFSF4 Antibody (FAB10541P).
 

Pathways for OX40 Ligand/TNFSF4 Antibody (FAB10541P)

View related products by pathway.

PTMs for OX40 Ligand/TNFSF4 Antibody (FAB10541P)

Learn more about PTMs related to OX40 Ligand/TNFSF4 Antibody (FAB10541P).

Blogs on OX40 Ligand/TNFSF4

There are no specific blogs for OX40 Ligand/TNFSF4, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our OX40 Ligand/TNFSF4 Antibody (159403) [Phycoerythrin] and receive a gift card or discount.

Bioinformatics

Gene Symbol TNFSF4
Uniprot