Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Immunogen affinity purified
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Nogo-A Antibody
Nogo-A, also known as Reticulon-4, is the longest of four splice
variants of Nogo. It is a CNS myelin-associated neurite outgrowth
inhibitor that is highly expressed in oligodendrocytes. Nogo-A is
synthesized as an 1163 amino acid protein and lacks a signal peptide.
Within conserved C-terminal reticulon homology domain (RHD), two
transmembrane domains, which are separated by a 66 amino acid
extracellular loop, exist. Both the N-terminal domain and the 66 amino
acid domain (Nogo-66) can be detected on the cell surface and show
neurite outgrowth inhibitory activity. The amino acid sequence of rat
Nogo-A N-terminal domain is 76% identical to that of human Nogo-A.
Within the RHD domain, rat Nogo-A shares 99% and 97% amino acid
sequence identity with mouse and human Nogo, respectively.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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