NMDAR2A Antibody

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Western Blot: NMDAR2A Antibody [NB300-296]

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

NMDAR2A Antibody Summary

Immunogen
Fusion protein from the C-terminus region of the NR2A subunit of rat NMDA receptor.
Localization
Cell membrane
Specificity
Specific for the ~180k NR2A subunit of the NMDA receptor. No reactivity towards the NR2B and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRIN2A
Purity
Unpurified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
This antibody has been tested in Western blot, detecting a band ~180 kDa.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Neat whole antisera
Preservative
No Preservative
Purity
Unpurified

Alternate Names for NMDAR2A Antibody

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A
  • hNR2A
  • NMDA receptor subtype 2A
  • N-methyl D-aspartate receptor subtype 2A
  • N-methyl-D-aspartate receptor subunit 2A
  • subunit epsilon-1

Background

The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GRIN2A
Entrez
Uniprot